Article
Species-specific agonist/antagonist activities of human interleukin-4 variants suggest distinct ligand binding properties of human and murine common receptor gamma chain.
The Journal of biological chemistry - 14 Apr 1995
Bönsch D, Kammer W, Lischke A, Friedrich K
Abstract excerpt
Interleukin-4 (IL-4) is a pleiotropic cytokine eliciting various responses in target cells upon binding to its receptor. Activation of the IL-4 receptor probably involves interaction of the ligand with both the IL-4 receptor alpha subunit (IL-4R alpha) and the common gamma chain (c gamma). Althou...
Topics
- Amino Acid Sequence
- Animals
- Arginine
- Base Sequence
- Cell Line
- DNA Primers
- Humans
- Interleukin-4
- Ligands
- Mice
- Molecular Sequence Data
- Mutation
- Receptors, Granulocyte Colony-Stimulating Factor
- Sequence Alignment
- Signal Transduction
- Species Specificity