Article
Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles.
Cell - 7 Apr 1995
Glover D M, Leibowitz M H, McLean D A, Parry H
Abstract excerpt
We show that female sterile mutations of aurora (aur) are allelic to mutations in the lethal complementation group ck10. This lies in a cytogenetic interval, 87A7-A9, that contains eight transcription units. A 250 bp region upstream of both aur and a divergent transcription unit corresponds to th...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Aurora Kinases
- Brain
- Centrosome
- Chromosome Walking
- Cloning, Molecular
- DNA, Complementary
- Drosophila
- Female
- Genes, Insect
- Genes, Lethal
- Genetic Complementation Test
- Mitosis
- Molecular Sequence Data
- Mutation
- Protein Serine-Threonine Kinases