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Article

Polo kinase and progression through M phase in Drosophila: a perspective from the spindle poles.

Oncogene - 10 Jan 2005

Glover David M

Abstract excerpt

Genes for the mitotic kinases Polo and Aurora A were first identified in Drosophila through screens of maternal effect lethal mutations for defects in spindle pole behaviour. These enzymes have been shown to be highly conserved and required for multiple functions in mitosis. Polo is stabilized at the centrosome by association with Hsp90. It is required for centrosome maturation on M-phase entry in order to...

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Source

Identifiers

PMID: 15640838
DOI: 10.1038/sj.onc.1208279

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Polo kinase and progression through M phase in Drosophila: a perspective from the spindle poles.PMID 15640838Read ↗

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Roles of Pdk1p, a fission yeast protein related to phosphoinositide-dependent protein kinase, in the regulation of mitosis and cytokinesis.Semantic proximity Read ↗

Polo kinase regulates the localization and activity of the chromosomal passenger complex in meiosis and mitosis in Drosophila melanogaster.Semantic proximity Read ↗

polo encodes a protein kinase homolog required for mitosis in Drosophila.Semantic proximity Read ↗

The Drosophila POLO kinase localises to multiple compartments of the mitotic apparatus and is required for the phosphorylation of MPM2 reactive epitopes.Semantic proximity Read ↗

Aurora-A: the maker and breaker of spindle poles.Semantic proximity Read ↗

Mutations in mákos, a Drosophila gene encoding the Cdc27 subunit of the anaphase promoting complex, enhance centrosomal defects in polo and are suppressed by mutations in twins/aar, which encodes a regulatory subunit of PP2A.Semantic proximity Read ↗

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