Article
Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production.
Nature genetics - 1 Feb 1995
Pollock J D, Williams D A, Gifford M A, Li L L, Du X, Fisherman J, Orkin S H, Doerschuk C M, Dinauer M C
Abstract excerpt
Chronic granulomatous disease (CGD) is a recessive disorder characterized by a defective phagocyte respiratory burst oxidase, life-threatening pyogenic infections and inflammatory granulomas. Gene targeting was used to generate mice with a null allele of the gene involved in X-linked CGD, which encodes the 91 kD subunit of the oxidase cytochrome b. Affected hemizygous male mice lacked phagocyte superoxide...
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