Article
Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production.
Nature genetics - 1 Feb 1995
Pollock J D, Williams D A, Gifford M A, Li L L, Du X, Fisherman J, Orkin S H, Doerschuk C M, Dinauer M C
Abstract excerpt
Chronic granulomatous disease (CGD) is a recessive disorder characterized by a defective phagocyte respiratory burst oxidase, life-threatening pyogenic infections and inflammatory granulomas. Gene targeting was used to generate mice with a null allele of the gene involved in X-linked CGD, which e...
Topics
- Alleles
- Animals
- Aspergillosis
- Aspergillus fumigatus
- Cytochrome b Group
- Disease Models, Animal
- Female
- Genetic Linkage
- Granulomatous Disease, Chronic
- Lung Diseases, Fungal
- Macrophages
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Neutrophils
- Peritonitis
- Phagocytes