Article
The respiratory burst oxidase and the molecular genetics of chronic granulomatous disease.
Critical reviews in clinical laboratory sciences - 1 Jan 1993
Dinauer M C
Abstract excerpt
The phagocyte respiratory burst oxidase plays a central role in the inflammatory response. This membrane-bound enzyme complex is comprised of both integral membrane and cytosolic proteins and catalyzes the formation of large quantities of superoxide in response to inflammatory stimuli. While superoxide and its oxidant derivatives normally serve a microbicidal function, excessive or inappropriate release of these...
Topics
- Cytochrome b Group
- Flavoproteins
- GTP-Binding Proteins
- Genetic Linkage
- Granulomatous Disease, Chronic
- Humans
- Models, Biological
- Mutation
- NADH, NADPH Oxidoreductases
- NADPH Oxidases
- Respiratory Burst