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Article

Invasive aspergillosis in chronic granulomatous disease

1 Jan 2009

Abstract excerpt

Chronic granulomatous disease (CGD) is an inherited disorder of the NADPH oxidase complex in which phagocytes are defective in generating superoxide anion and its metabolites. NADPH oxidase activation leads to activation of sequestered neutrophil proteases that mediate host defense. Invasive aspergillosis and other rarer mold diseases are the leading causes of mortality in CGD, reflecting the key role of the...

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PMID: 19296367
DOI: 10.1080/13693780902736620

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