The genetic basis of chronic granulomatous disease.

doi:10.1111/j.1600-065x.1994.tb00850.x

Back to search

Article

The genetic basis of chronic granulomatous disease.

Immunological reviews - 1 Apr 1994

Roos D

Abstract excerpt

Chronic granulomatous disease is a serious clinical entity. The disease is caused by the failure of NADPH oxidase in phagocytic leukocytes to generate superoxide, needed for the killing of micro-organisms. The patients need careful management aimed at prevention and aggressive treatment of infect...

Topics

Female
Granulomatous Disease, Chronic
Humans
Male
Mutation
NADH, NADPH Oxidoreductases
NADPH Oxidases
Phagocytes
Superoxides

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.