Article
Exclusion of the candidate locus FSP1 in six families with late-onset autosomal dominant spastic paraplegia.
Neuromuscular disorders : NMD - 1 Jan 1995
Fontaine B, Rime C S, Hazan J, Dürr A, Stevanin G, Penet C, Reboul J, Agid Y, Lyon-Caen O, Baumann N
Abstract excerpt
Hereditary spastic paraplegias are neurological hereditary conditions of unknown aetiology. In pure spastic paraplegia, most of the pedigrees display an autosomal dominant mode of inheritance. A gene for pure autosomal dominant spastic paraplegia (ADSP), termed FSP1, was mapped to chromosome 14q...
Topics
- Adolescent
- Adult
- Age of Onset
- Aged
- Base Sequence
- Child
- Child, Preschool
- Chromosome Mapping
- Chromosomes, Human, Pair 14
- Family
- Female
- France
- Genes, Dominant
- Genetic Linkage
- Genotype
- Humans
- Male
- Middle Aged