A novel locus for pure recessive hereditary spastic paraplegia maps to 10q22.1-10q24.1.

doi:10.1002/ana.20239

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Article

A novel locus for pure recessive hereditary spastic paraplegia maps to 10q22.1-10q24.1.

Annals of neurology - 1 Oct 2004

Meijer Inge A, Cossette Patrick, Roussel Julie, Benard Melanie, Toupin Sylvie, Rouleau Guy A

Abstract excerpt

The hereditary spastic paraplegias (HSPs) are a group of clinically and genetically heterogeneous disorders characterized by progressive lower-limb spasticity. In this study, we performed linkage analysis on an autosomal recessive pure HSP family and mapped the disease to chromosome 10q22.1-10q24.1, a locus partially overlapping the existing SPG9 locus. We have either identified a novel locus for pure recessive...

Topics

Chromosome Mapping
Chromosomes, Human, Pair 10
Family Health
Female
Genes, Recessive
Genetic Linkage
Genetic Markers
Genotype
Humans
Male
Pedigree
Polymorphism, Genetic
Spastic Paraplegia, Hereditary

Source

Open in PubMed

Identifiers

PMID: 15455396
DOI: 10.1002/ana.20239

Provenance

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