Article
[The selection of cold-adapted variants of the influenza viruses H1N1 and H3N2 and their antigenic and genetic characteristics].
Voprosy virusologii - 1 Jan 2000
Podcherniaeva R Ia, Döhner L, Medvedeva T E, Aleksandrova G I
Abstract excerpt
As a result of serial passages (42 passages) at low temperatures (26 degrees--28 degrees C) of two influenza H1N1 and H3N2 virus strains stable cold-adapted (ca) variants were produced. Investigations of them showed the ca A/USSR/03/84 (H1N1) variant to have ts-mutations in genes 1, 2, 4, 5, 7, a...
Topics
- Adaptation, Physiological
- Animals
- Antigens, Viral
- Chick Embryo
- Cold Temperature
- Genetic Variation
- Influenza A Virus, H1N1 Subtype
- Influenza A Virus, H3N2 Subtype
- Influenza A virus
- Influenza Vaccines
- Mutation
- Recombination, Genetic
- Selection, Genetic
- Temperature
- Vaccines, Attenuated