Article
Genetic Basis of Attenuation of Cold-Adapted Influenza Strain B/Leningrad/14/17/55 - Backup Master Donor Virus for Influenza Type B Live Attenuated Vaccines.
Bulletin of experimental biology and medicine - 1 Mar 2020
Krutikova E V, Stepanova E A, Wong P F, Kiseleva I V, Grigor'eva E P, Rudenko L G
Abstract excerpt
The reassortant vaccine strain of live attenuated influenza vaccine inherits temperature sensitivity and areactogenicity from cold-adapted attenuated master donor virus. In Russia, B/ USSR/60/69 master donor virus (B60) is currently in use for the preparation of live attenuated type B influenza vaccine candidates. Trivalent live attenuated influenza vaccine based on A/ Leningrad/134/17/57 and B60 are licensed for...
Topics
- Adaptation, Physiological
- Animals
- Chick Embryo
- Cold Temperature
- Genes, Viral
- Genetic Association Studies
- Humans
- Influenza B virus
- Influenza Vaccines
- Influenza, Human
- Mice
- Phenotype
- Russia
- Temperature