Signaling through the epidermal growth factor receptor during the development of malignancy.

doi:10.1016/j.pharmthera.2004.01.002

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Article

Signaling through the epidermal growth factor receptor during the development of malignancy.

Pharmacology & therapeutics - 1 Apr 2004

Grandis Jennifer Rubin, Sok John C

Abstract excerpt

The epidermal growth factor receptor (EGFR) is overexpressed and/or constitutively activated in a variety of human malignancies. Detection of increased expression levels of EGFR in cancer and the association between overexpression and decreased patient survival has led to the development of several therapeutic strategies to target this receptor. The results of early-phase clinical trials to date suggest that...

Topics

Animals
ErbB Receptors
Humans
Mutation
Neoplasms
Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 15056497
DOI: 10.1016/j.pharmthera.2004.01.002

Genes

EGFR

Provenance

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