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Article

HIV Integration Site Selection: Targeting in Macrophages and the Effects of Different Routes of Viral Entry

5 May 2006

Abstract excerpt

We have studied the selection of HIV DNA integration sites in primary macrophages to investigate two questions. First, mature macrophages do not divide, allowing us to investigate whether HIV integration targeting differs between dividing cells and nondividing cells. We sequenced and analyzed 754 unique integration sites and found that integration in macrophages is favored in active transcription units (TUs), as...

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Identifiers

PMID: 16647883
DOI: 10.1016/j.ymthe.2006.03.012

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