Human immunodeficiency virus type 1 integrase: effects of mutations on viral ability to integrate, direct viral gene expression from unintegrated viral DNA templates, and sustain viral propagation in primary cells.

doi:10.1128/JVI.69.1.376-386.1995

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Article

Human immunodeficiency virus type 1 integrase: effects of mutations on viral ability to integrate, direct viral gene expression from unintegrated viral DNA templates, and sustain viral propagation in primary cells.

Journal of virology - 1 Jan 1995

Wiskerchen M, Muesing M A

Abstract excerpt

Integrase is the only viral protein necessary for integration of retroviral DNA into chromosomal DNA of the host cell. Biochemical analysis of human immunodeficiency virus type 1 (HIV-1) integrase with purified protein and synthetic DNA substrates has revealed extensive information regarding the...

Topics

Base Sequence
Cell Line
DNA Nucleotidyltransferases
DNA, Viral
Gene Expression Regulation, Viral
HIV-1
Humans
Integrases
Lymphocytes
Macrophages
Molecular Sequence Data
Mutation
Phenotype
Templates, Genetic
Virus Integration
Virus Replication

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Identifiers

PMID: 7983732
DOI: 10.1128/JVI.69.1.376-386.1995
PMCID: PMC188585

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7983732-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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