Article
Essential role of vif in establishing productive HIV-1 infection in peripheral blood T lymphocytes and monocyte/macrophages.
Journal of acquired immune deficiency syndromes - 1 Sept 1994
Gabuzda D H, Li H, Lawrence K, Vasir B S, Crawford K, Langhoff E
Abstract excerpt
The role of vif during the establishment of human immunodeficiency virus type 1 (HIV-1) infection of peripheral blood T lymphocytes and monocyte/macrophages was investigated using vif mutants of three HIV-1 proviral DNAs. Vif was found to be essential for the establishment of productive HIV-1 inf...
Topics
- Cell Line
- Cells, Cultured
- DNA, Viral
- Gene Products, vif
- Genome, Viral
- HIV Core Protein p24
- HIV Reverse Transcriptase
- HIV-1
- HeLa Cells
- Humans
- Macrophages
- Monocytes
- Mutation
- Open Reading Frames
- Proviruses
- RNA-Directed DNA Polymerase
- T-Lymphocytes
- Transfection