Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic analysis of the human immunodeficiency virus type 1 integrase protein

1 Mar 1994

Abstract excerpt

Single-amino-acid changes in a highly conserved central region of the human immunodeficiency virus type 1 (HIV-1) integrase protein were analyzed for their effects on viral protein synthesis, virion morphogenesis, and viral replication. Alteration of two amino acids that are invariant among retroviral integrases, D116 and E152 of HIV-1, as well as a mutation of the highly conserved amino acid S147 blocked viral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV/AIDS drug development and treatment
Share to HIV/AIDS Research and Interventions
Share to HIV Research and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8107224
DOI: 10.1128/jvi.68.3.1633-1642.1994

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic analysis of the human immunodeficiency virus type 1 integrase proteinPMID 8107224Read ↗

Human immunodeficiency virus type 1 integrase: effect on viral replication of mutations at highly conserved residuesSemantic proximity Read ↗

Requirement for Integrase during Reverse Transcription of Human Immunodeficiency Virus Type 1 and the Effect of Cysteine Mutations of Integrase on Its Interactions with Reverse TranscriptaseSemantic proximity Read ↗

Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication.Semantic proximity Read ↗

Human immunodeficiency virus type 1 integrase: effects of mutations on viral ability to integrate, direct viral gene expression from unintegrated viral DNA templates, and sustain viral propagation in primary cells.Semantic proximity Read ↗

Mutational scan of the human immunodeficiency virus type 2 integrase protein.Semantic proximity Read ↗

Sequential Deletion of the Integrase (Gag-Pol) Carboxyl Terminus Reveals Distinct Phenotypic Classes of Defective HIV-1Semantic proximity Read ↗

Genetic analyses of DNA-binding mutants in the catalytic core domain of human immunodeficiency virus type 1 integrase.Semantic proximity Read ↗

Biochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integraseSemantic proximity Read ↗

Multimodal Functionalities of HIV-1 IntegraseSemantic proximity Read ↗

Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infectionSemantic proximity Read ↗

A mutation in integrase can compensate for mutations in the simian immunodeficiency virus att site.Semantic proximity Read ↗

Identification of Amino Acid Residues in APOBEC3G Required for Regulation by Human Immunodeficiency Virus Type 1 Vif and Virion EncapsidationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.