Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

VH and VL gene usage by anti-beta-amyloid autoantibodies in Alzheimer's disease: detection of highly mutated V regions in both heavy and light chains.

Clinical immunology and immunopathology - 1 May 1995

Fang Q, Kannapell C C, Fu S M, Xu S, Gaskin F

Abstract excerpt

In a previous study, four human IgM kappa monoclonal antibodies (mAbs) secreted by Epstein-Barr-virus-transformed B cell lines independently derived from the peripheral blood of a patient with Alzheimer's disease (AD) were found to react with a conformational epitope of beta-amyloid protein and to stain amyloid plaques in AD brain. Three of these mAbs were studied further. They did not react with an additional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Antibodies, Monoclonal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Autoantibodies

Share to Base Sequence

Share to Immunoglobulin Heavy Chains

Share to Immunoglobulin Variable Region

Share to Molecular Sequence Data

Share to Mutation

Source

Identifiers

PMID: 7704974
DOI: 10.1006/clin.1995.1066

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

VH and VL gene usage by anti-beta-amyloid autoantibodies in Alzheimer's disease: detection of highly mutated V regions in both heavy and light chains.PMID 7704974Read ↗

Human anti-Gal heavy chain genes. Preferential use of VH3 and the presence of somatic mutations.Semantic proximity Read ↗

Variable region genes of anti-HIV human monoclonal antibodies: non-restricted use of the V gene repertoire and extensive somatic mutation.Semantic proximity Read ↗

The normally expressed kappa immunoglobulin light chain gene repertoire and somatic mutations studied by single-sided specific polymerase chain reaction (PCR); frequent occurrence of features often assigned to autoimmunity.Semantic proximity Read ↗

Evidence that amyloidogenic light chains undergo antigen-driven selection.Semantic proximity Read ↗

Analysis of V(lambda)-J(lambda) expression in plasma cells from primary (AL) amyloidosis and normal bone marrow identifies 3r (lambdaIII) as a new amyloid-associated germline gene segment.Semantic proximity Read ↗

Germline structure and differential utilization of Igha and Ighb VH10 genes.Semantic proximity Read ↗

Human lupus anti-DNA autoantibodies undergo essentially primary V kappa gene rearrangements.Semantic proximity Read ↗

Clonal immunoglobulin light chain variable region germline gene use in AL amyloidosis: association with dominant amyloid‐related organ involvement and survival after stem cell transplantationSemantic proximity Read ↗

VH genes expressed in peripheral blood IgE-producing B cells from patients with atopic dermatitis.Semantic proximity Read ↗

Primary structure of a variable region of the VκI subgroup (<i>ISE</i>) in light chain deposition diseaseSemantic proximity Read ↗

Can isotype switch modulate antigen-binding affinity and influence clonal selection?Semantic proximity Read ↗

Age-related alterations of somatic hypermutation and CDR3 lengths in human Vkappa4-expressing B lymphocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.