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Article

VH and VL gene usage by anti-beta-amyloid autoantibodies in Alzheimer's disease: detection of highly mutated V regions in both heavy and light chains.

Clinical immunology and immunopathology - 1 May 1995

Fang Q, Kannapell C C, Fu S M, Xu S, Gaskin F

Abstract excerpt

In a previous study, four human IgM kappa monoclonal antibodies (mAbs) secreted by Epstein-Barr-virus-transformed B cell lines independently derived from the peripheral blood of a patient with Alzheimer's disease (AD) were found to react with a conformational epitope of beta-amyloid protein and to stain amyloid plaques in AD brain. Three of these mAbs were studied further. They did not react with an additional...

Topics

Alzheimer Disease
Amyloid beta-Peptides
Antibodies, Monoclonal
Antigenic Variation
Autoantibodies
Base Sequence
Humans
Immunoglobulin Heavy Chains
Immunoglobulin Light Chains
Immunoglobulin Variable Region

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin kappa-Chains

Molecular Sequence Data

Mutation

Source

Identifiers

PMID: 7704974
DOI: 10.1006/clin.1995.1066

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7704974-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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