Article
Age-related alterations of somatic hypermutation and CDR3 lengths in human Vkappa4-expressing B lymphocytes.
Immunology - 1 Jun 1999
Troutaud D, Drouet M, Decourt C, Le Morvan C, Cogné M
Abstract excerpt
The lower avidity and/or affinity of antibodies generated by an aged immune system could be attributed to two major changes in the antibody repertoire: a shift in germline gene usage and a decrease in the rate of immunoglobulin hypermutation. In an attempt to identify the mechanisms involved in t...
Topics
- Adult
- Aged
- Aged, 80 and over
- Aging
- B-Lymphocyte Subsets
- Base Sequence
- Genetic Variation
- Humans
- Immunoglobulin J-Chains
- Immunoglobulin Variable Region
- Immunoglobulin kappa-Chains
- Middle Aged
- Molecular Sequence Data
- Mutation
- Reverse Transcriptase Polymerase Chain Reaction