Article
Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability.
Nature genetics - 1 Jan 1995
Liu B, Nicolaides N C, Markowitz S, Willson J K, Parsons R E, Jen J, Papadopolous N, Peltomäki P, de la Chapelle A, Hamilton S R
Abstract excerpt
Microsatellite instability has been observed in both sporadic and hereditary forms of colorectal cancer. In the hereditary form, this instability is generally due to germline mutations in mismatch repair (MMR) genes. However, only one in ten patients with sporadic tumours exhibiting microsatellite instability had a detectable germline mutation. Moreover, only three of seven sporadic tumour cell lines with...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Animals
- Base Sequence
- Colorectal Neoplasms
- DNA Primers
- DNA Repair
- DNA, Neoplasm
- DNA, Satellite