Article
Clinicopathologic features in colorectal cancer patients with microsatellite instability.
Mutation research - 21 Dec 2004
Raut Chandrajit P, Pawlik Timothy M, Rodriguez-Bigas Miguel A
Abstract excerpt
The microsatellite instability (MSI) mutational pathway is critical to carcinogenesis in a small but significant proportion of colorectal cancers. While MSI is identified in most cancers in individuals with hereditary non-polyposis colorectal cancer, the majority of MSI tumors are found in individuals with sporadic disease. Colorectal cancers arising as a result of MSI have distinct clinicopathologic features...
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