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Article

Microsatellite instability in human solid tumors.

Molecular medicine today - 1 Feb 1997

Lothe R A

Abstract excerpt

A genome-wide instability has been found in almost all analyzed malignant tumors from patients with hereditary non-polyposis colorectal cancer (HNPCC), and in a subgroup of sporadic (non-inherited) cancers of the same type. This mutator phenotype was initially seen as novel alleles at microsatellite loci (a family of repetitive DNA sequences) and was shown to be caused by mutations in the highly conserved...

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PMID: 9060003
DOI: 10.1016/S1357-4310(96)10055-1

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