Article
Functional double-negative T cells in the periphery express T cell receptor V beta gene products that cause deletion of single-positive T cells.
European journal of immunology - 1 Jan 1993
Martínez C, Marcos M A, de Alboran I M, Alonso J M, de Cid R, Kroemer G, Coutinho A
Abstract excerpt
A proportion of peripheral T cells lack surface expression of the CD4 or CD8 coreceptor molecules and hence are designated as " double negative" (DN). Most DN T lymphocytes express the gamma/delta T cell receptor (TcR), but a minor fraction of them, in both humans and mice, express the alpha/beta TcR. Whereas alpha/beta+ DN T lymphocytes are infrequent (< 1%) in conventional lymphoid organs (spleen, blood, lymph...
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