Article
Absence of linkage between radiosensitivity and the predisposing atp7b gene mutation for heritable hepatitis in the LEC rat.
Radiation research - 1 Jul 2000
Ogiu T, Nishimura M, Watanabe F, Ukai H, Ishii-Ohba H, Shimada Y, Tsuji H, Sakurai J, Hino O
Abstract excerpt
The LEC rat is known to be a mutant strain that spontaneously develops heritable hepatitis due to copper accumulation, caused by mutation of the copper-transporting ATPase gene (Atp7b). Immunodeficiency and radiosensitivity have also been observed. Hayashi et al. extensively examined the radiosensitivity of the LEC rat and concluded that its hypersensitivity is controlled by a single autosomal gene. Furthermore,...
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