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Article

Mechanism of interferon action. Biochemical and genetic evidence for the intermolecular association of the RNA-dependent protein kinase PKR from human cells.

Virology - 1 Jan 1996

Ortega L G, McCotter M D, Henry G L, McCormack S J, Thomis D C, Samuel C E

Abstract excerpt

The interferon-inducible protein kinase (PKR) is activated by an RNA-dependent autophosphorylation. Structure-function studies of the 551 amino acid PKR kinase from human cells have revealed that catalytic-deficient PKR mutants such as PKR(1-551)K296R display a dominant negative behavior when expressed in transfected cells. The potential for PKR to form protein multimers has therefore been examined. Three types...

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Source

Identifiers

PMID: 8553584
DOI: 10.1006/viro.1996.0004

Genes

BCL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mechanism of interferon action. Biochemical and genetic evidence for the intermolecular association of the RNA-dependent protein kinase PKR from human cells.PMID 8553584Read ↗

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Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways.Semantic proximity Read ↗

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Enhanced antiviral and antiproliferative properties of a STAT1 mutant unable to interact with the protein kinase PKR.Semantic proximity Read ↗

The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR).Semantic proximity Read ↗

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