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Article

Dominant Negative Function by an Alternatively Spliced Form of the Interferon-inducible Protein Kinase PKR

1 Apr 2001

Abstract excerpt

The double-stranded RNA (dsRNA)-activated protein kinase PKR (protein kinase dsRNA-dependent) plays an important role in the regulation of protein synthesis by phosphorylating the alpha-subunit of eukaryotic initiation factor 2. Through this activity, PKR is thought to mediate the antiviral and antiproliferative actions of interferon. Here, we show that the human T cell leukemia Jurkat cells express an...

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PMID: 11278390
DOI: 10.1074/jbc.m008140200

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Dominant Negative Function by an Alternatively Spliced Form of the Interferon-inducible Protein Kinase PKRPMID 11278390Read ↗

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