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Article

Mechanism of PKR activation: dimerization and kinase activation in the absence of double-stranded RNA.

Journal of molecular biology - 7 Jan 2005

Lemaire Peter A, Lary Jeffrey, Cole James L

Abstract excerpt

The kinase PKR is a central component of the interferon antiviral pathway. PKR is activated upon binding double-stranded (ds) RNA to undergo autophosphorylation. Although PKR is known to dimerize, the relationship between dimerization and activation remains unclear. Here, we directly characterize dimerization of PKR in free solution using analytical ultracentrifugation and correlate self-association with...

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Identifiers

PMID: 15567412
DOI: 10.1016/j.jmb.2004.10.031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mechanism of PKR activation: dimerization and kinase activation in the absence of double-stranded RNA.PMID 15567412Read ↗

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