Article
Characterization of human immunodeficiency virus type-1 (HIV-1) particles that express protease-reverse transcriptase fusion proteins.
Journal of molecular biology - 20 Nov 1998
Cherry E, Liang C, Rong L, Quan Y, Inouye P, Li X, Morin N, Kotler M, Wainberg M A
Abstract excerpt
We have selectively mutagenized specific residues at the junction between the protease (PR) and reverse transcriptase (RT) genes of human immunodeficiency virus type 1 (HIV-1) to study the effects of PR-RT fusion proteins in the context of a full-length, infectious proviral construct. Mutant viru...
Topics
- Animals
- Anti-HIV Agents
- COS Cells
- HIV Protease
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Jurkat Cells
- Microscopy, Electron
- Mutation
- RNA, Viral
- Recombinant Fusion Proteins
- Viral Proteins