Function of the SOS process in repair of DNA damage induced by modern 4-quinolones.

doi:10.1111/j.2042-7158.1993.tb05673.x

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Article

Function of the SOS process in repair of DNA damage induced by modern 4-quinolones.

The Journal of pharmacy and pharmacology - 1 Jul 1993

Howard B M, Pinney R J, Smith J T

Abstract excerpt

The recA13 mutant of Escherichia coli strain K-12, which lacks recombination and SOS error-prone DNA repair is hypersensitive to nalidixic acid and to the newer 4-quinolones ciprofloxacin, norfloxacin and ofloxacin. However, whereas recombination-proficient but SOS repair-deficient strains, such...

Topics

Anti-Infective Agents
Cell Division
Ciprofloxacin
DNA Damage
DNA Repair
DNA, Bacterial
Escherichia coli
Mutation
Nalidixic Acid
Norfloxacin
Ofloxacin
RNA, Bacterial
SOS Response, Genetics

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