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Article

A class of gyrase mutants of Salmonella typhimurium show quinolone-like lethality and require rec functions for viability.

Molecular microbiology - 1 Jul 1996

Garí E, Figueroa-Bossi N, Blanc-Potard A B, Spirito F, Schmid M B, Bossi L

Abstract excerpt

We have identified a new class of DNA gyrase mutants of Salmonella typhimurium that show chronic derepression of the SOS regulon. Thus, these mutants mimic the response of wild-type cells to gyrase inhibitors of the quinolone family. SOS induction by conditional lethal mutations gyrA208 or gyrB652, like that mediated by quinolones, is completely dependent on the function of the recB gene product. Introduction of...

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Identifiers

PMID: 8843438
DOI: 10.1046/j.1365-2958.1996.6221338.x

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Source receipt: pubmed, retrieved 7 Sept 2026.

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