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Article

Genetic analysis of the requirements for SOS induction by nalidixic acid in Escherichia coli.

Gene - 15 Aug 2005

Newmark Kathryn G, O'Reilly Erin K, Pohlhaus Jennifer Reineke, Kreuzer Kenneth N

Abstract excerpt

Nalidixic acid, the prototype antibacterial quinolone, induces the SOS response by a mechanism that requires the RecBCD nuclease/helicase. A key step inferred for this induction pathway is the conversion of a drug-induced gyrase cleavage complex into a DNA break that can be processed by RecBC. We tried to clarify the nature of this step by searching for additional gene products that are specifically necessary for...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16005583
DOI: 10.1016/j.gene.2005.04.029
PMCID: PMC2200294

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic analysis of the requirements for SOS induction by nalidixic acid in Escherichia coli.PMID 16005583Read ↗

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