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Article

Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide.

1 Jun 1994

Abstract excerpt

TCR rearrangements were used to probe the clonal origin of myelin basic protein (MBP)-reactive T cells from patients with multiple sclerosis (n = 7) and normal subjects (n = 3). The majority of MBP-specific T cell lines were specific for the immunodominant MBP(84-102) and MBP(143-168) peptides and were restricted by HLA-DR molecules. In two patients with the DR2 haplotype, the T cell response to MBP was focused...

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Identifiers

PMID: 7514641
DOI: 10.4049/jimmunol.152.11.5581

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Source receipt: pubmed, retrieved 7 Sept 2026.

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