Article
Activation of a myelin basic protein-specific human T cell clone by antigen-presenting cells from rhesus monkeys.
International immunology - 1 Sept 1995
Meinl E, t Hart B A, Bontrop R E, Hoch R M, Iglesias A, de Waal Malefyt R, Fickenscher H, Müller-Fleckenstein I, Fleckenstein B, Wekerle H
Abstract excerpt
This study addresses the capacity of peripheral blood mononuclear cells (PBMC) from rhesus monkeys (Macaca mulatta) to present myelin basic protein (MBP), a candidate auto-antigen for multiple sclerosis, to MBP-specific human CD4+ T cell clones. MHC-restriction of the human T cell clones was dete...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Antigen-Presenting Cells
- Base Sequence
- Clone Cells
- Coculture Techniques
- HLA-DR Antigens
- HLA-DRB1 Chains
- Humans
- Lymphocyte Activation
- Macaca mulatta
- Molecular Sequence Data
- Myelin Basic Protein
- T-Lymphocytes