Article
Activation of a myelin basic protein-specific human T cell clone by antigen-presenting cells from rhesus monkeys.
International immunology - 1 Sept 1995
Meinl E, t Hart B A, Bontrop R E, Hoch R M, Iglesias A, de Waal Malefyt R, Fickenscher H, Müller-Fleckenstein I, Fleckenstein B, Wekerle H
Abstract excerpt
This study addresses the capacity of peripheral blood mononuclear cells (PBMC) from rhesus monkeys (Macaca mulatta) to present myelin basic protein (MBP), a candidate auto-antigen for multiple sclerosis, to MBP-specific human CD4+ T cell clones. MHC-restriction of the human T cell clones was determined with HLA-DR-transfected L cells, and epitope specificity was established with a panel of overlapping 20-mer...
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