Infrequent involvement of p53 gene mutations in the tumourigenesis of Japanese prostate cancer.

Abstract excerpt

A study was made of the incidence of p53 mutations in Japanese males with prostate cancer or benign prostatic hyperplasia. Polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) was used as a primary screening technique with gene sequencing being carried out in positive cases. Two out of 21 prostate cancers (9.5%) were found to have p53 mutations. These were stage B2 and D2 prostate cancers....

Topics

• Adenocarcinoma
• Base Sequence
• Genes, p53
• Humans
• Japan
• Male
• Molecular Sequence Data
• Mutation
• Polymerase Chain Reaction
• Prostatic Hyperplasia
• Prostatic Neoplasms