Article
p53 Codon 72 and p21 codon 31 polymorphisms in prostate cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2004
Huang Shu-Pin, Wu Wen-Jeng, Chang Wun-Shaing Wayne, Wu Ming-Tsang, Chen Yun-Yun, Chen Yun-Ju, Yu Chia-Cheng, Wu Tony T, Lee Ying-Huei, Huang Jong-Khing, Huang Chun-Hsiung
Abstract excerpt
The tumor suppressor gene p53 and its downstream effector p21 are thought to play major roles in the development of human malignancy. Polymorphic variants of p53 at codon 72, and p21 at codon 31, have been found to be associated with cancer susceptibility, but few studies have investigated their effect on prostate cancer risk. In this case-control study, we investigated the association of p53 codon 72 and p21...
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