Article
B- and T-lymphocyte micronuclei in chimney sweeps with respect to genetic polymorphism for CYP1A1 and GST1 (class Mu).
Mutation research - 1 Oct 1993
Carstensen U, Alexandrie A K, Högstedt B, Rannug A, Bratt I, Hagmar L
Abstract excerpt
Epidemiological studies have shown an increased incidence of lung cancer, bladder cancer, and esophageal cancer in chimney sweeps, probably due to their exposure to PAH in soot. The work environment for sweeps has, however, improved during the last decades. It was thus important to assess whether the present exposure still may cause genotoxic effects. A further objective was to assess whether genetic...
Topics
- Adult
- Aged
- Air Pollution
- B-Lymphocytes
- Carbon
- Case-Control Studies
- Cells, Cultured
- Cytochrome P-450 Enzyme System
- Genetic Predisposition to Disease
- Genotype
- Glutathione Transferase