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Micronuclei frequency in peripheral blood lymphocytes and cancer risk: evidence from human studies

16 Dec 2010

Abstract excerpt

Over a century ago, Theodor Boveri paved the way to mechanistic studies linking chromosomal abnormalities to cancer pathogenesis. Since then, theoretical and empirical evidence has been accumulated, supporting a causal role of these events in the aetiology of human cancer. A powerful tool for measurement of chromosomal abnormalities is the cytokinesis-block micronucleus cytome (CBMNcyt) assay. The validation of...

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PMID: 21164188
DOI: 10.1093/mutage/geq075

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