Article
Lack of association between GSTT1 polymorphism and endogenous or benzo[a]pyrene-induced sister chromatid exchanges as analyzed in metaphase or G2-phase lymphocytes.
Molecular biology reports - 1 Aug 2011
Hatzi V I, Terzoudi G I, Stavropoulou C, Malik S I, Makropoulos V, Pantelias G E
Abstract excerpt
The objectives of the present work are (1) to verify whether genetic polymorphism in the detoxification gene GSTT1 influences the endogenous sensitivity in terms of sister chromatid exchanges (SCEs)/cell in healthy donors and (2) to test whether in vitro exposure to B[a]P in terms of SCEs/cell can be associated with polymorphism of GSTT1 gene. The presence or absence of the homozygous deletion in GSTT1 gene was...
Topics
- Benzo(a)pyrene
- G2 Phase
- Genotype
- Glutathione Transferase
- Humans
- Lymphocytes
- Metaphase
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Sister Chromatid Exchange
- Tissue Donors