Article
Aromatic DNA adducts, micronuclei and genetic polymorphism for CYP1A1 and GST1 in chimney sweeps.
Carcinogenesis - 1 Jul 1994
Ichiba M, Hagmar L, Rannug A, Högstedt B, Alexandrie A K, Carstensen U, Hemminki K
Abstract excerpt
Aromatic DNA adducts in total white blood cells, cytochrome P450 (CYP) class 1A1 and glutathione transferase (GST1) class mu genotypes and micronuclei in T- and B-lymphocytes were studied in 69 full-time chimney sweeps and 35 controls, all male subjects. The sweeps had a higher (22%) but statisti...
Topics
- Adult
- Aged
- Cytochrome P-450 Enzyme System
- DNA
- Genotype
- Glutathione Transferase
- Humans
- Isoenzymes
- Lymphocytes
- Male
- Micronuclei, Chromosome-Defective
- Middle Aged
- Occupational Exposure
- Polycyclic Compounds
- Polymorphism, Genetic