Article
Association of polymorphisms in AhR, CYP1A1, GSTM1, and GSTT1 genes with levels of DNA damage in peripheral blood lymphocytes among coke-oven workers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2006
Chen Yongwen, Bai Yun, Yuan Jing, Chen Weihong, Sun Jianya, Wang Hong, Liang Huashan, Guo Liang, Yang Xiaobo, Tan Hao, Su Yougong, Wei Qingyi, Wu Tangchun
Abstract excerpt
Accumulating evidence has shown that both DNA damage caused by the metabolites of polycyclic aromatic hydrocarbons (PAH) and genetic polymorphisms in PAH-metabolic genes contribute to individual susceptibility to PAH-induced carcinogenesis. However, the functional relevance of genetic polymorphisms in PAH-metabolic genes in exposed individuals is still unclear. In this study of 240 coke-oven workers (the exposed...
Topics
- Adult
- Coke
- Cytochrome P-450 CYP1A1
- DNA Damage
- Genotype
- Glutathione Transferase
- Humans
- Lymphocytes
- Male
- Occupational Exposure
- Polycyclic Aromatic Hydrocarbons
- Polymorphism, Genetic