Article
Amsacrine and etoposide hypersensitivity of yeast cells overexpressing DNA topoisomerase II.
Cancer research - 15 Aug 1992
Nitiss J L, Liu Y X, Harbury P, Jannatipour M, Wasserman R, Wang J C
Abstract excerpt
Increasing the cellular concentration of DNA topoisomerase II in yeast by expressing constitutively a plasmid-borne TOP2 gene encoding the enzyme greatly increases the sensitivity of the cells to amsacrine and etoposide (VP-16). This increased drug sensitivity at a higher intracellular DNA topois...
Topics
- Amsacrine
- DNA Topoisomerases, Type II
- Etoposide
- Gene Expression Regulation, Enzymologic
- Genes, Fungal
- Mutation
- Plasmids
- Saccharomyces cerevisiae