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Article

Amsacrine and etoposide hypersensitivity of yeast cells overexpressing DNA topoisomerase II.

Cancer research - 15 Aug 1992

Nitiss J L, Liu Y X, Harbury P, Jannatipour M, Wasserman R, Wang J C

Abstract excerpt

Increasing the cellular concentration of DNA topoisomerase II in yeast by expressing constitutively a plasmid-borne TOP2 gene encoding the enzyme greatly increases the sensitivity of the cells to amsacrine and etoposide (VP-16). This increased drug sensitivity at a higher intracellular DNA topoisomerase II level is observed in both RAD52+ repair-proficient strains and rad52 mutants that are defective in the...

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Source

Identifiers

PMID: 1322791

Genes

RAD52

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Amsacrine and etoposide hypersensitivity of yeast cells overexpressing DNA topoisomerase II.PMID 1322791Read ↗

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The top2-5 mutant of yeast topoisomerase II encodes an enzyme resistant to etoposide and amsacrine.Semantic proximity Read ↗

Atypical multidrug resistance may be associated with catalytically active mutants of human DNA topoisomerase II alpha.Semantic proximity Read ↗

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