Article
Forward-mutation tests on the antitumor agent ICR-170 in Neurospora crassa demonstrate that it induces gene/point mutations in the ad-3 region and an exceptionally high frequency of multiple-locus ad-3 mutations with closely linked sites of recessive lethal damage.
Mutation research - 1 Oct 1994
de Serres F J, Malling H V
Abstract excerpt
The mutagenicity of the antitumor agent ICR-170 (2-methoxy-6-chloro-9-[(ethyl-2-chloroethyl)amino propylamino] acridine dihydrochloride) in the adenine-3 (ad-3) region was studied with a two-component heterokaryon (H-12) of Neurospora crassa. The objective was to characterize the genetic damage p...
Topics
- Adenine
- Alleles
- Aminoacridines
- Animals
- Antineoplastic Agents
- DNA Mutational Analysis
- Dose-Response Relationship, Drug
- Genes, Lethal
- Genes, Recessive
- Genetic Complementation Test
- Kinetics
- Mice
- Mutagenicity Tests
- Mutagens