The role of mitochondrial DNA mutations and free radicals in disease and ageing.

Abstract excerpt

Considerable efforts have been made to understand the role of oxidative stress in age-related diseases and ageing. The mitochondrial free radical theory of ageing, which proposes that damage to mitochondrial DNA (mtDNA) and other macromolecules caused by the production of reactive oxygen species (ROS) during cellular respiration drives ageing, has for a long time been the central hypothesis in the field. However,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Aging
• Share to Alzheimer Disease
• Share to DNA, Mitochondrial