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An update on the oxygen stress-mitochondrial mutation theory of aging: genetic and evolutionary implications.

Experimental gerontology - 1 Jan 2000

Miquel J

Abstract excerpt

The acceleration of fixed-postmitotic cell aging by a high metabolic rate and the age related loss of mitochondria found in that cell type led us to propose an oxygen stress-mitochondrial mutation theory of aging, according to which senescence may be linked to mutations of the mitochondrial genome (mtDNA) of the irreversibly differentiated cells. This extranuclear somatic gene mutation concept of aging is...

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PMID: 9467721
DOI: 10.1016/s0531-5565(97)00060-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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