An update on the oxygen stress-mitochondrial mutation theory of aging: genetic and evolutionary implications.

doi:10.1016/s0531-5565(97)00060-0

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Article

An update on the oxygen stress-mitochondrial mutation theory of aging: genetic and evolutionary implications.

Experimental gerontology - 1 Jan 2000

Miquel J

Abstract excerpt

The acceleration of fixed-postmitotic cell aging by a high metabolic rate and the age related loss of mitochondria found in that cell type led us to propose an oxygen stress-mitochondrial mutation theory of aging, according to which senescence may be linked to mutations of the mitochondrial genom...

Topics

Aging
Animals
Biological Evolution
DNA, Mitochondrial
Drosophila
Energy Metabolism
Humans
Mutation
Oxidative Stress
Stochastic Processes

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