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Article

Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancers.

Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1992

Davidoff A M, Iglehart J D, Marks J R

Abstract excerpt

Overexpression of the p53 protein, resulting from gene mutations that increase protein stability, has been detected in greater than 25% of primary human breast cancers. In addition, approximately 10% of breast cancer patients have circulating antibodies to the p53 protein. In this study, the anti-p53 humoral response is correlated with the presence and type of mutant p53 protein expressed in the tumor. In a...

Topics

Antibodies, Monoclonal
Base Sequence
Breast Neoplasms
Cell Line
Codon
Epitopes
Female
Genes, p53
Heat-Shock Proteins
Humans
Immunoblotting
Methionine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

RNA, Messenger

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 1373500
DOI: 10.1073/pnas.89.8.3439
PMCID: PMC48883

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1373500-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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