Article
Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancers.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1992
Davidoff A M, Iglehart J D, Marks J R
Abstract excerpt
Overexpression of the p53 protein, resulting from gene mutations that increase protein stability, has been detected in greater than 25% of primary human breast cancers. In addition, approximately 10% of breast cancer patients have circulating antibodies to the p53 protein. In this study, the anti-p53 humoral response is correlated with the presence and type of mutant p53 protein expressed in the tumor. In a...
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