Article
Suppression of c-Src activity by C-terminal Src kinase involves the c-Src SH2 and SH3 domains: analysis with Saccharomyces cerevisiae.
Molecular and cellular biology - 1 Sept 1993
Murphy S M, Bergman M, Morgan D O
Abstract excerpt
The kinase activity of c-Src is normally repressed in vertebrate cells by extensive phosphorylation of Y-527. C-terminal Src kinase (CSK) is a candidate for the enzyme that catalyzes this phosphorylation. We have used budding yeast to study the regulation of c-Src activity by CSK in intact cells. Expression of c-Src in Saccharomyces cerevisiae, which lacks endogenous c-Src and Y-527 kinases, induces a...
Topics
- CSK Tyrosine-Protein Kinase
- Cell Division
- DNA Mutational Analysis
- Oncogene Protein pp60(v-src)
- Phenotype
- Phosphoproteins
- Phosphorylation
- Phosphotyrosine
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins pp60(c-src)