Article
Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src.
The EMBO journal - 1 Jul 1993
Superti-Furga G, Fumagalli S, Koegl M, Courtneidge S A, Draetta G
Abstract excerpt
The protein tyrosine kinase c-Src is negatively regulated by phosphorylation of Tyr527 in its carboxy-terminal tail. A kinase that phosphorylates Tyr527, called Csk, has recently been identified. We expressed c-Src in yeast to test the role of the SH2 and SH3 domains of Src in the negative regulation exerted by Tyr527 phosphorylation. Inducible expression of c-Src in Schizosaccharomyces pombe caused cell death....
Topics
- Amino Acid Sequence
- CSK Tyrosine-Protein Kinase
- Cloning, Molecular
- Genes, Lethal
- Molecular Sequence Data
- Mutation
- Peptides
- Phenotype
- Phosphorylation
- Protein Conformation
- Protein-Tyrosine Kinases