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Article

Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src.

The EMBO journal - 1 Jul 1993

Superti-Furga G, Fumagalli S, Koegl M, Courtneidge S A, Draetta G

Abstract excerpt

The protein tyrosine kinase c-Src is negatively regulated by phosphorylation of Tyr527 in its carboxy-terminal tail. A kinase that phosphorylates Tyr527, called Csk, has recently been identified. We expressed c-Src in yeast to test the role of the SH2 and SH3 domains of Src in the negative regulation exerted by Tyr527 phosphorylation. Inducible expression of c-Src in Schizosaccharomyces pombe caused cell death....

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Identifiers

PMID: 7687537
DOI: 10.1002/j.1460-2075.1993.tb05923.x
PMCID: PMC413509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src.PMID 7687537Read ↗

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