A variant epithelial sub-population in normal thyroid with high proliferative capacity in vitro.

doi:10.1016/0303-7207(93)90121-y

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Article

A variant epithelial sub-population in normal thyroid with high proliferative capacity in vitro.

Molecular and cellular endocrinology - 1 Jun 1993

Bond J A, Wyllie F S, Ivan M, Dawson T, Wynford-Thomas D

Abstract excerpt

We describe the existence in normal human primary thyroid cultures of a hitherto unrecognised sub-population of epithelial cells. This variant phenotype is characterised by squamoid morphology, absence of thyroglobulin, and an altered profile of intermediate filament expression. We suggest that t...

Topics

Biomarkers
Cell Differentiation
Cell Division
Cells, Cultured
Epithelial Cells
Genes, ras
Genetic Vectors
Humans
Keratins
Metaplasia
Phenotype
Selection, Genetic
Thyroid Gland
Transfection

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