Article
Humanized medium (h7H) allows long-term primary follicular thyroid cultures from human normal thyroid, benign neoplasm, and cancer.
The Journal of clinical endocrinology and metabolism - 1 Jun 2013
Bravo Susana B, Garcia-Rendueles Maria E R, Garcia-Rendueles Angela R, Rodrigues Joana S, Perez-Romero Sihara, Garcia-Lavandeira Montserrat, Suarez-Fariña Maria, Barreiro Francisco, Czarnocka Barbara, Senra Ana, Lareu Maria V, Rodriguez-Garcia Javier, Cameselle-Teijeiro Jose, Alvarez Clara V
Abstract excerpt
CONTEXT: Mechanisms of thyroid physiology and cancer are principally studied in follicular cell lines. However, human thyroid cancer lines were found to be heavily contaminated by other sources, and only one supposedly normal-thyroid cell line, immortalized with SV40 antigen, is available. In primary culture, human follicular cultures lose their phenotype after passage. We hypothesized that the loss of the...
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