Article
The development of larger cells that spontaneously escape senescence--a step during the immortalization of a human cancer cell line.
Journal of cellular and molecular medicine - 1 Jan 2000
Diaconu Carmen C, Bleotu Coralia, Chivu Mihaela, Alexiu Irina, Petrusca Daniela, Anton Gabriela, Achim Ruxandra, Ruta Simona M, Cernescu C
Abstract excerpt
There are few information concerning the changes associated with the transition interval when slow growing, primary explanted human cancer cells are displaced by new selected faster growing cells and became an immortal cell line. In a previous paper (J. Cell. Mol. Med., 5: 49-59, 2001) we described the TV cell line derived from a laryngeal tumor which harbors human papillomavirus (HPV) gene sequences throughout...
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