Genotoxic potential of psoralen cross-links versus monoadducts in normal human lymphoblasts.

doi:10.1016/0165-7992(95)90050-0

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Article

Genotoxic potential of psoralen cross-links versus monoadducts in normal human lymphoblasts.

Mutation research - 1 Mar 1995

Laquerbe A, Moustacchi E, Papadopoulo D

Abstract excerpt

Using the 4,5',8-trimethylpsoralen in combination with the reirradiation protocol, we show that, in normal human lymphoblasts, the cytotoxic potential of photoinduced cross-links (CL) is higher than that of monoadducts (MA). In contrast to cytotoxicity, the significant increase in the proportion...

Topics

Cell Line
Cell Survival
DNA Adducts
Dose-Response Relationship, Radiation
Humans
Hypoxanthine Phosphoribosyltransferase
Lymphocytes
Mutagenicity Tests
Mutation
Species Specificity
Trioxsalen
Ultraviolet Rays

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